Fast Dissolving Tablets (FDT)) are most accepted and exploited for the drug delivery for the patients who are having difficulty with swallowing i.e., mainly pediatric’s and Geriatric’s. Amlodipine besylate (ADB) is an anti-hypertensive and it is also used in many Coronary artery diseases, Whereas Rosuvastatin Calcium (RSC) is an anti-hyperlipidemia that prevents of Atheroma. The aim of the paper was to formulate a combined oral dosage form of amlodipine besylate and rosuvastatin calcium into fast dissolving tablet using three super disintegrants such as Croscarmellose Sodium (CCS), Cross povidone (CP), Sodium Starch Glycolate (SSG) at various concentrations to enhance the disintegration and dissolution of ADB and RSC to improve bioavailability of the drugs. The tablets were prepared by using direct compression method and evaluated for weight variations, Hardness, Friability, Wetting time, Disintegration time and Dissolution study. Prepared tablets are subject to FT-IR Study for Characterization and compatibility study. No Chemical interaction between drug and excipients were indicated in the FT-IR. Disintegration and dissolution profiles decreases with addition of super disintegrating agents like Croscarmellose Sodium (CCS), Cross povidone (CP), Sodium Starch Glycolate (SSG). Among all the formulation FD6 with CP in 10% and SSG 5% Concentration found to be best in drug release profile. The results showed that super disintegrants used in combinations shows better disintegrating property. Among all formulations, promising formulation FD6 showed good wetting time (26 sec), fastest disintegration time (55 sec) and maximum drug release of 99.89% within 5 minutes.
The papaya is the fruit of the plant Carica papaya, the sole species in the genus Carica of the plant family Caricaceae. The papaya is a large, tree-like plant, with a single stem growing from 5 to 10 m (16 to 33 ft) tall, with spirally arranged leaves confined to the top of the trunk. The lower trunk is conspicuously scarred where leaves and fruit were borne.It consists of high content of zeaxthin, proteolytic enzymes like papain and chymo papain, vitmin K, β-carotene, other phytoconstituents like polyphenols, sugars, aromatic amino acids and sulphur containing amino acids, phytosterols, starch and nutrients e. g P, S, K, Ca, Fe, Mg etc and had good health protective effects. The main objective of the present work is to evaluate the anticancer activity of various extracts of fruit of Carica papaya against Human Prostate cancer cell line DU-145. DU-145 and PC3 human prostate cancer cell lines are the “classical” cell lines of prostatic cancer DU145 cells have moderate metastatic potential compared to PC3 cells which have high metastatic potential The DU145 cell line was derived from brain metastasis. SRB assay was used to analyze the cell growth inhibition. From the present studied it had been displayed that CFE, ELE and MLE, all were exhibiting the potential capability to kill the cancer cell when compared with standard drug 5-FU. The cell growth inhibition by various extracts of fruit of Carica papaya was varied due to the presence of varying concentration of bioactive compounds. CFE had displayed the highest cell growth inhibition (94.52 %) at 6.25 µg (IC50 = 2.2 µg/ml) due to the presence of polyphenols (flavanoids), ELE with the 93.83% growth inhibition at 6.25 µg (IC50 = 2.4 µg/ml) and MLE with the 92.80% % growth inhibition at 6.25 µg (IC50 = 2.6 µg/ml).
Urinary Tract Infection (UTI) remains the most common bacterial infection in human population. The squealae of complicated UTIs are substantial. It is well established that in the presence of obstruction, calculus, Diabetes mellitus, and other risk factors, UTIs can lead to progressive renal damage. The aim of this study was to determine bacterial agents responsible for urinary tract infection and to evaluate their susceptibility pattern. Urine sample was cultured on Cystine Lactose Electrolyte Deficient (CLED) media by calibrated loop technique. Antimicrobial susceptibility testing was performed by Kirby bauer disc diffusion method. Out of 320 samples, 155 samples revealed growth of one type of bacteria, and 15 showed growth of 2 types of bacteria. E. Coli was most common bacteria (115/185=62.16%) followed by other enterobacteriaceae, Pseudomonas and a few gram positive cocci. Many bacteria were found to be multidrug resistant while most of gram negative bacteria were susceptible to Imipenem, and most of gram positive bacteria were susceptible to linezolid.
Chrysanthemum plant is an ayurvedic important medicinal plant, and modern systems of medicine, flowers are the most important part in the field for preparation of various drugs. The present study aimed to focused objective was to study the two flower extracts with methanol and ethanol solvents and its antimicrobial activity both bacteria (Staphylococcus and Pseudomonas strains) and fungi (Candida species). When the C. indicum plant leaf extract treated with the experimental organisms of three strains Pseudomonas strains clearly showed that the maximum and minimum zone of inhibition was noticed on PA-38, 8±1.38 and PA- 37, 4±0.11. Similarly, ethanolic extract illustrated that the higher activity of this strain PA-39, 11±2.68 as well as PA-38, revealed the observed the value of 9±0.65 minimum effect on ethanolic extract. While, the C. cinerariaefolium ethanolic flower extract was treated with three different strains of Pseudomonas maximum similar zone of inhibition was noticed against PA-37 (10 ±2.75) and PA-38 (10 ±2.65). It was statistically significant as well as highest response when compared with Ciprofloxacin. Amoung the two plants C. indicum possessed excellent antimicrobial activity on both bacteria and fungi than the C. cinerariaefolium plant leaf. Subsequently the present research analyzed flower of the C. indicum plant by GC-MS techniques in order to determine the majority compounds. Totally 18 compounds were analyzed, amoung the 18 analytes camphor is an important peak compound also it contains 19.5 and 0.60% retention time and abundance respectively. Furthermore C. indicum possessed second most compound is Isoborneol, it was probably noticed 0.410% of abundance and its retention time is 17.5. Additionally two compounds also been observed as a sub peak level such as γ- Cadinene Methyl ester and Chrysanthenol. Hence, the current result clearly showed that the C. indicum plant flower is act as a very good potential antimicrobial agent.
Objectives: To analyze trends in the LSCS rate and to analyze the indications of LSCS in modern day practice.
Place and duration: The study was carried out over a period of seven months (from June 2013 to December 2013) at GMERS medical college, sola, Ahmedabad.
Methodology: Total no of patients delivered were counted and total no. of LSCS done was found. For the LSCS patients, parameters like elective or emergency, parity status, indications of LSCS, were noted and analyzed.
Result: Frequency of LSCS in the study period was 25.18%. The indications of LSCS in order of frequency were previous one LSCS in 173 (42.09%) patients, followed by fetal distress in 45 (10.94%); failure to progress in 45 (10.94%),previous 2 LSCS in 28(6.81%),CPD and Breech in 26 cases(6.32%)each, mal-presentation & PIH in 8(1.94%) cases each, antepartum haemorrhage in 10 (2.43%); twin in 7 (1.7%) and oligoamnios and/or IUGR in 16(3.89%).
Conclusion: LSCS rate is higher than advised by WHO and previous LSCS is the commonest indication followed by fetal distress. Obstetrical audit will help us a lot in reducing the rate.