Aim of the study: Aloe vera is a medicinal plant widely distributed in the various parts of India. Aloe Vera is a major medicinal plant when it comes to treating and protecting the skin. Used externally, it is very effective on burns and sunburn, as well as a variety of skin diseases (eczema, pruritus, psoriasis, acne) – it is extremely constructive and protective. Root contains resinous matter and fat. It is used as Stomachic hepato-biliary affections etc. The present research was aimed to evaluate the potential hepatoprotective activity of ethanol and aqueous extracts of stem using in vivo models to validate the folkloric use of the plant.
Materials and methods: The hepatoprotective activity of the ethanol and aqueous extracts of stem were studied on male albino wistar rats, liver damage induced by paracetamol (2.5gm/kg, p.o.) by monitoring biochemical parameters. Various biochemical parameters were studied to evaluate the hepatoprotective activity of ethanol and aqueous extracts in serum like glutamic pyruvic transaminase (sGPT), serum glutamic oxaloacetic transaminase (sGOT) and serum alkaline phosphatase (sALP), total bilirubin (sB), total protein, total cholesterol and histopathological changes in liver were also studied along with silymarin (100mg/kg, p.o.) as standard hepatoprotective agents were determined to assess the effect of the ethanol and aqueous extracts of stem of Aloe vera (100 and 200 mg/kg) on the paracetamol induced hepatic damage.
Conclusions: The results indicate that this plant possesses potential hepatoprotective properties and has therapeutic potential for the treatment of liver diseases.
Results: The phytochemical investigation of the extracts showed presence of carbohydrates, proteins, steroids and flavonoids. Pre-treatment of the rats with ethanol and aqueous extracts prior to paracetamol administration caused a significant reduction in the values of sGOT, sGPT, sALP and sB (P<0.01) almost comparable to the silymarin. The hepatoprotective was confirmed by histopathological examination of the liver tissue of control and treated animal.