Fast Dissolving Tablets (FDT)) are most accepted and exploited for the drug delivery for the patients who are having difficulty with swallowing i.e., mainly pediatric’s and Geriatric’s. Amlodipine besylate (ADB) is an anti-hypertensive and it is also used in many Coronary artery diseases, Whereas Rosuvastatin Calcium (RSC) is an anti-hyperlipidemia that prevents of Atheroma. The aim of the paper was to formulate a combined oral dosage form of amlodipine besylate and rosuvastatin calcium into fast dissolving tablet using three super disintegrants such as Croscarmellose Sodium (CCS), Cross povidone (CP), Sodium Starch Glycolate (SSG) at various concentrations to enhance the disintegration and dissolution of ADB and RSC to improve bioavailability of the drugs. The tablets were prepared by using direct compression method and evaluated for weight variations, Hardness, Friability, Wetting time, Disintegration time and Dissolution study. Prepared tablets are subject to FT-IR Study for Characterization and compatibility study. No Chemical interaction between drug and excipients were indicated in the FT-IR. Disintegration and dissolution profiles decreases with addition of super disintegrating agents like Croscarmellose Sodium (CCS), Cross povidone (CP), Sodium Starch Glycolate (SSG). Among all the formulation FD6 with CP in 10% and SSG 5% Concentration found to be best in drug release profile. The results showed that super disintegrants used in combinations shows better disintegrating property. Among all formulations, promising formulation FD6 showed good wetting time (26 sec), fastest disintegration time (55 sec) and maximum drug release of 99.89% within 5 minutes.